IMC-001 (anti-PD-L1 mAb)
PD-L1 is a clinically validated immune-checkpoint target which is over-expressed on tumor cells and tumor-infiltrating immune cells in multiple tumor types. PD-L1 is responsible for inhibiting the natural antitumor immune response by deactivating cytotoxic T cells in the tumor microenvironment or preventing priming and activation of new T cells in the lymph nodes thereby preventing their recruitments to the tumor. Antibodies blocking PD-L1 can reactivate T-cell activity and proliferation, leading to enhanced anti-tumor immunity.
IMC-001 is a fully human anti-PD-L1 monoclonal antibody which shows robust efficacy both in vitro and in vivo. We have successfully completed a Phase I study of IMC-001 in February 2019 and a global Phase II study is planned.
IMC-002 (anti-CD47 mAb)
CD47 is a transmembrane protein broadly expressed on cell’s surface and often overexpressed on cancer cells. CD47 on cancer cells interacts with the myeloid inhibitory immunoreceptor SIRPα on macrophages to deliver a “don’t-eat me” signal that inhibits phagocytic activity (cancer cell killing). Blocking CD47-SIRPα interaction restores phagocytic activity of macrophages, which was shown to inhibit tumor growth in mouse xenograft model.
IMC-002 is a fully human IgG monoclonal antibody that binds human CD47 with an optimal affinity that maximizes efficacy (tumor phagocytosis) without causing hemagglutination. IMC-002 blocks CD47-SIRPα interaction to promote phagocytosis of cancer cells by macrophages. Combinational blockade of PD-L1 and CD47 has been shown to enhance anti-tumor effects in vivo. This presents an interesting opportunity to combine IMC-001 and IMC-002 in the clinic. ImmuneOncia is also developing additional antibodies targeting novel immune-checkpoints.
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